Abstract
Objective: To observe the different preparations miacalcic combined with ossification in three alcohol for hemodialysis in patients with renal osteodystrophy treatment effect.Method:106 patients who got the renal bone disease with higher parathyroid hormone (PTH) and hyperphosphatemia caused by hemodialysis were selected, and at the same time, they presented with clinical symptoms, and were divided into the treatment group and the control group according to the research methods of prospectie randomized and controlled, 53 cases in each group, all the patients in the treatment of the underlying disease, dialysis (blood or peritoneal dialysis), complement calcium and Calcitriol; the treatment group was given Calcitonin nasal spray 200 IU, 1 times a day before 2 weeks, then 1 times on alternate days, 3 months for a course. The control group was given Miacalcic injection 50 IU, intramuscular injection, 1 times a day before 2 weeks, 1 times on alternate days in 3 and 4 weeks, then 2 times a week. After 3 months, the changes of renal osteopathy symptoms and serum phosphorus, serum calcium, PTH of two groups before and after treatment were observed.Result:After the treatment, symptoms of renal osteodystrophy was improved significantly, serum phosphorus, serum PTH decreased significantly, serum calcium level, the treatment group before treatment, serum calcium, phosphorus, parathyroid hormone (PTH) were (2.04±0.27), (2.78±0.31), (858.50±119.98), after treatment were (2.36±0.19), (2.18±0.21), (719.79±120.14); the control group before treatment were (2.11±0.39), (2.87±0.23), (891.45±124.73), after treatment were (2.39±0.34), (2.19±0.13), (721.69±117.56); serum calcium, serum phosphorus and PTH were changed significantly before and after treatment in both groups (P<0.05), but no significant differences were observed between the two groups (P>0.05); the pain symptoms of two groups were improved obviously, but in the relief time, the treatment group was better than that of the control group, the difference was statistically significant (P<0.05); and the treatment group was less side effects.Conclusion: Calcitonin on renal osteopathy treatment of nasal spray with little side effect, more convenient, practical, good tolerance, and can quickly relieve pain.关键词
骨化三醇/密钙息/肾性骨病Key words
Ossification in three alcohol/Calcitonin/Renal osteodystrophy
