中国医学创新Issue(14)：7-9,10,4.DOI:10.3969/j.issn.1674-4985.2014.14.003
大电导钙激活钾通道β1亚基与子痫前期的相关性研究
Correlation Study of Large Conductance Ca2+-Activated K+-Channel β1 Subunit Interacts with Preeclampsia
王书宏 1徐琳 1颜丽丽2
作者信息
- 1. 青岛大学医学院附属医院 山东 青岛 266003
- 2. 山东省蓬莱市妇幼保健站
- 折叠
摘要
Abstract
Objective:To investigate the relationship between the pathogenesis of preeclampsia(PE)and the mRNA and protein expression of KCNMβ1 subunit in placenta and uterine smooth muscle tissue.Method:The pregnant placenta tissue and KCNMβl mRNA expression in uterine smooth muscle tissue of the mild and severe preeclampsia group(the study group)and the normal pregnant women(the control group)were detected by fluorescent quantitative PCR technique. The serum KCNMβl concentration level changes of three groups pregnant women were detected by ELISA method. Result:The pregnant women’serum level of KCNM βl,placenta and uterus smooth muscle in KCNM βl mRNA expression levels of the research group were significantly lower than the control group,the difference had statistical significance(P<0.05);there were no significant difference between the mild and severe preeclampsia group(P>0.05). Conclusion:KCNMβl expression in serum of pregnant women is reduced,the placenta tissue and smooth muscle of the uterus KCNMβl mRNA expression in lower closely associated with the onset of preeclampsia,may be involved in the pathophysiological process of preeclampsia.关键词
子痫前期/大电导钙激活钾通道β1亚基/胎盘/子宫平滑肌/血清Key words
Preeclampsia/Large conductance Ca2+-activated K+-channelβ1 subunit/Placenta/Uerine smooth muscle tissue/Blood serum引用本文复制引用
王书宏,徐琳,颜丽丽..大电导钙激活钾通道β1亚基与子痫前期的相关性研究[J].中国医学创新,2014,(14):7-9,10,4.
