中国医学创新Issue(15)：74-77,4.DOI:10.3969/j.issn.1674-4985.2014.15.027
接尘煤工慢阻肺临床及支气管黏膜病理研究
The Clinical and Bronchial Mucosa Pathological Study of Workers Exposed to Dusts with Chronic Obstructive Pulmonary Disease
张群 1孙学会 1陈继忠 1侯杰 1郭辉 1侯乐志1
作者信息
- 1. 山东枣庄矿业集团中心医院 山东 枣庄 277800
- 折叠
摘要
Abstract
Objective:To investigate the influence factors on clinical curative effect of workers exposed to dusts with chronic obstructive pulmonary disease(COPD).Method:93 patients with chronic obstructive pulmonary disease and coal-worker’s pneumoconiosis in our hospital from January 2010 and April 2013 were selected as research subjects,they were randomly divided into workers exposed to dusts with chronic obstructive pulmonary disease group (35 cases)and non workers exposed to dusts with chronic obstructive pulmonary disease group(30 cases)and coal-worker’s pneumoconiosis group(28 cases).All patients’ disease were evaluated by COPD assessment test.And patients were treated with bronchoscopy and biopsy after informed consent,the changes of bronchoscope of gross observation and biopsy histology in each group were compared and researched.The first two COPD patients were given the same treatment, and observed its clinical effect.Result:Used the same treatment found that the CAT and FEV1 of workers exposed to dusts with COPD patients were significantly lower than those in non workers exposed to dusts with COPD patients.Large airway mucosa changes of workers exposed to dusts with COPD patients and coal worker's pneumoconiosis patients roughly the same,but to a lesser degree.Compared with non workers exposed to dusts with COPD group,it showed that special change:such as mucosal surface of the black area,deformation of luminal stenosis,submucosal fibrous tissue hyperplasia and so on.Conclusion:Bronchial morphological and histological changes are the main reason lead to the poor clinical therapy effect on workers exposed to dusts with COPD compared with non workers exposed to dusts with COPD in the same condition of COPD.关键词
煤矿工人/慢性阻塞性肺疾病/支气管镜检查/病理学Key words
Coal mine workers/Chronic obstructive pulmonary disease/Bronchoscopy/Pathology引用本文复制引用
张群,孙学会,陈继忠,侯杰,郭辉,侯乐志..接尘煤工慢阻肺临床及支气管黏膜病理研究[J].中国医学创新,2014,(15):74-77,4.
