中国医学创新Issue(16)：31-34,4.DOI:10.3969/j.issn.1674-4985.2014.16.010
不同剂量罗库溴铵与琥珀胆碱运用于麻醉状态下无抽搐电休克治疗肌松效果的比较
The Comparison between Therapeutic Effect of Neuromuscular Blocking Using Modified Electroshock Therapy with Different Doses of Rocuronium and Suxamethonium under Anesthesia
张莉 1杨保仲 2汪祖巾 2王春燕 2贾文霞2
作者信息
- 1. 山西医科大学 山西 太原 030001
- 2. 山西医科大学第一医院
- 折叠
摘要
Abstract
Objective:To discuss the influence of different doses of rocuronium and suxamethonium applied to modified electroshock therapy( ECT) under anesthesia to treat mental patient with neuromuscular blocking. Method:Patients diagnosed as mental illness should be chosen and must be characterized by explicit electroshock therapy indications. The classification of ASA was at I level and their ages should be between 18 and 50.All patients received ECT for three times a week and must received ECT for at average about six times at least. 60 patients were divided into three groups according to random number table method,the control group was 1 mg/kg suxamethonium group( the group S), the treatment groups were 0.3 mg/kg( the group R1) rocuronium group and 0.45 mg/kg( the group R2) rocuronium group, all these groups should be respectively combined with propofol(1 mg/kg) as anesthesia induction. After ECT, neostigmine (0.1 mg/kg)and atropine(0.05 mg/kg) antagonism rocuronium were added to the two group doses of rocuronium. Consequently, the comparison shall be made among three patients on the recovery time of automatic respiration, the time to open eyes, the time of body movement as well as the heart rate and the change of blood pressure and oxygen saturation before electroshock and during electroshock.Result: The patients’ automatic respiration recovery time of the R2 group were significantly longer than the other groups, the differences were statistical significance( P<0.05).There were no statistical significance in the time of opening eyes and body movement among the three groups(P>0.05);no matter before electroshock or during electroshock, there were no statistical significance in patients’ HR, the change of BP and SpO2 among three groups(P>0.05). Conclusion:0.45 mg/kg rocuronium can result in extending the recovery time of patients’ automatic respiration.,so it’s not supported to be applied to modified electroshock therapy; 0.3 mg/kg rocuronium used with neuromuscular blocking antagonist can be the replacement for suxamethonium being applied to modified electroshock therapy.关键词
电休克治疗/骨骼肌松弛药/罗库溴铵/琥珀胆碱Key words
Electroshock therapy/Neuromuscular blocking agent/Rocuronium/Suxamethonium引用本文复制引用
张莉,杨保仲,汪祖巾,王春燕,贾文霞..不同剂量罗库溴铵与琥珀胆碱运用于麻醉状态下无抽搐电休克治疗肌松效果的比较[J].中国医学创新,2014,(16):31-34,4.
