摘要
Abstract
Objective:To observe effects of hemodynamics on Dexmedetomidine pretreatment for thoracic surgery in older individuals via double lumen endotracheal intubation in General anesthetic induction period. Method:Forty ASAⅠ-Ⅲpatients with thoracic surgery were randomly divided into two groups:Group C(control group,n=20)and Group D(dexmedetomidine group D,n=20). In the group D,Dexmedetomidine was intravenously administered at 0.5μg/kg for ten minutes. The patients in Group C were stated on 0.9%normal saline infusion at an equivalent rate. Drug induced using midazolam 0.02 mg/kg,fentanyl 4μg/kg,vecuronium bromide 0.1 mg/kg and etomidate 0.3 mg/kg. Changes of cerebral state index(CSI),heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP)were monitored before injection(T0),after injection at 2 minutes(T1),4 minutes(T2),6 minutes(T3),8 minutes(T4),10 minutes(T5),before intubation(T6),immediately after intubation(T7). Result:The CSI in Group D of T4(65.4±10.4),T5(60.3±7.9),T6(46.1±4.7)gradually decreased compared with the T0(96.5±4.0)(P<0.05),and was significantly less than that of Group C(P<0.05),the HR in Group D of T5,T6 significantly decreased compared with the T0(P<0.05). DBP,MAP,HR of T7 in Group C were higher than those of T6(P<0.05)during anesthetic induction. Conclusion:Dexmedetomidine pretreatment at 0.5μg/kg for ten minutes has obvious sedative effect for elderly patients,not only can make CSI decreased,but also can reduce the cardiovascular stress responses during double lumen endotracheal intubation.关键词
右美托咪定/全麻诱导期/老年患者/双腔气管插管/血流动力学Key words
Dexmedetomidine/Induction of general anesthesia/General patient/Double lumen endotracheal tube/Hemodynamics
