中国医学创新Issue(18)：12-14,3.DOI:10.3969/j.issn.1674-4985.2014.18.004
PNPLA3基因多态性与原发性肝癌遗传易感性的相关性研究
The Correlation Study of PNPLA3 Gene Polymorphism and Genetic Susceptibility to Hepatocellular Carcinoma
摘要
Abstract
To explore the relationship between PNPLA3 I148M gene polymorphism and hepatocellular carcinoma(HCC),and discuss its pathogenesis.Method:67 patients with HCC and 69 cases of healthy control were selected as the subjects. The healthy control subjects had no family history of liver cancer and liver disease history. The sequence fragments of PNPLA3 rs738409 gene polymorphism in all cases were detected by utilizing the polymerase chain reaction(PCR)and gene sequencing orderly. Whether each genotype of the HCC group and the control group had group representation or not was based on Hardy-weinbeurg genetic equilibrium analysis. The genotype frequencies in cases and controls were compared by Chi-square test.Result:The HCC group and the control group were conformed with Hardy-Weinberg(H-W)balance(P>0.05). The 148 GG,148 CG,148 CC genotype frequency distribution had differences between the HCC group and the control group(X2=6.30,P<0.05).Conclusion:The rs738409 genetic phenotypes is obviously associated with primary liver cancer risk.关键词
PNPLA3/基因测序/原发性肝癌Key words
PNPLA3/Gene sequencing technology/Hepatocellular carcinoma引用本文复制引用
高超,王霞,李立红,周秀彦..PNPLA3基因多态性与原发性肝癌遗传易感性的相关性研究[J].中国医学创新,2014,(18):12-14,3.基金项目
山西省卫生厅资助项目 （）
