中国医学创新Issue(18)：36-38,3.DOI:10.3969/j.issn.1674-4985.2014.18.012
β-细辛醚对抑郁模型大鼠海马组织及Bax、Bcl-2的影响
Effect ofβ-asarone on the Hippocampus and the Expression of Protein Bax and Bcl-2 in Rat Model of Depression
摘要
Abstract
To investigate the effect ofβ-assrone on the hippocampus and the expressions of protein Bax and Bcl-2 in the hippocampus of depression model rats.Method:According to the open field test,adult Sprague-Dawley rates with similar scores were randomly divided into 4 groups,each group had 20 cases. Solitary and chronic mild unpredictability stimulation on each one except the normal control group,copy the model of depression. On the second day of a successful model replication,the fluoxetine control group and theβ-asarone group were given 1.2 mg/(kg·d)the fluoxetine and 25 mg/(kg·d)theβ-asarone. The model control group and the normal control group were given equal volumes of normal saline. On the 21th day,rats were to be put to death and take brain tissue. The protein expression of Bax and Bcl-2 in the hippocampus were tested by immunohistochemical staining method.Result:The numbers of neurons were reduced in the hippocampus of model group,scattered in the arrangement,the nucleus of neurons were pycnosis deformation,especially on the region of CA1 and CA3. Compared with model group,the protein expression of Bax reduced and Bcl-2 increased with statistical significance in the hippocampus in fluoxetine control group andβ-asarone group (P<0.01).Conclusion:β-asarone can reduce the protein expression of Bax,while promote the protein expression of Bcl-2 in the hippocampus of depression model rats.关键词
β-细辛醚/海马/B细胞淋巴瘤/白血病-2/BaxKey words
β-asarone/Hippocampus/B celll ymphoma/leukemis-2/Bcl-2 associated X protein引用本文复制引用
金铭,蔡珍珍,董海影,王俊平,荣华,张晓杰..β-细辛醚对抑郁模型大鼠海马组织及Bax、Bcl-2的影响[J].中国医学创新,2014,(18):36-38,3.基金项目
国家自然科学基金 （）
