摘要
Abstract
Objective:To investigate the clinical effect and therapeutic mechanism of large dose of recombinant human erythropoietin in the treatment of anemia of chronic renal failure(CRF).Method:58 patients with chronic renal failure anemia in our hospital from March 2012 to March 2014 were selected,all patients were treated with 12 000 IU rHuEPO subcutaneous injection,1 times a week,for 8 weeks.The patients were daily taken Ferrous Sulfate and Vitamin Complex Sustained-release Tablets 1 grains and regularly used vitamin B12 and folic acid.The patients’s bone marrow, blood,SI,SF and sideroblast count were detected.Result:In 58 patients,28 cases were markedly effective,26 cases were effective,4 cases were invalid,the total effective rate was 93.1%.After 2 weeks of treatment,Ret,RBC,Hb, Hct in patients began to increase,after 8 weeks of treatment,blood red line increased significantly compared with those before treatment,the differences were statistically significant(P<0.01).Red blood hyperplasia of bone marrow in patients with active significantly than before treatment,and early normoblast,young red,late erythroblasts and E value were significantly higher than those of before treatment,the late erythroid hyperplasia significantly,the G/E value decreased significantly compared with those before treatment,after treatment for 8 weeks in patients with SI,SF and iron bead young cells were significantly reduced,the differences were statistically significant(P<0.05).Conclusion:Large dose of recombinant human erythropoietin can be effectively used for the clinical treatment of patients with anemia in chronic renal failure,restore the body through a mechanism to stimulate bone marrow of normal hematopoietic function,it has broad prospects in the clinical treatment of patients with anemia in chronic renal failure..关键词
rHuEPO/肾衰竭贫血/骨髓象/机制Key words
rHuEPO/Anemia of chronic renal failure/Bone marrow/Mechanism
