摘要
Abstract
Objective:To observe the recent clinical efficacy of gemcitabine combined with radiotherapy in treatment of cervical cancer. Method:55 patients with advanced cervical cancer were randomly divided into two groups, A group(27 cases)was only treated with radiation therapy,and B group(28 cases)was treated with gemcitabine on the base of radiation therapy. The efficacy and adverse reactions of the two groups were compared. Result:The total effective rate of the B group was 85.7%,and that of the A group was 55.6%. There was differences between the two groups(P<0.01). The main adverse reactions of 14 patients in the A group showed weak,poor appetite,6 patients showed nausea,vomiting symptoms. The main adverse reactions of 15 patients in the B group showed weak,poor appetite,8 patients showed nausea,vomiting symptoms. 15 patients in the A group had Ⅰdegrees of bone marrow suppression,12 patients of Ⅱdegrees of bone marrow suppression,there was no Ⅲand Ⅳdegrees of bone marrow suppression. 16 patients in the B group hadⅠdegrees of bone marrow suppression,10 patients ofⅡdegrees of bone marrow suppression,2 patients ofⅢdegrees of bone marrow suppression,no Ⅳdegrees of bone marrow suppression. There was no difference about adverse reactions between the two groups(P>0.05). Conclusion:The methods of gemcitabine combined with radiotherapy can significantly improve short-term effect in the treatment of advanced cervical cancer,and adverse reactions could be tolerated by patients.关键词
宫颈癌/吉西他滨/放射治疗Key words
Cervical cancer/Gemcitabine/Radiation therapy
