摘要
Abstract
Objective:To investigate the level change of Adiponectin(ADPN),Omentin,Leptin in blood serum for patients with coronary artery heart disease.Method:30 healthy people in our hospital were regarded as control group,34 patients with coronary heart disease were regarded as CHD group,41 patients with coronary artery heart diseases combined with type 2 diabetes were regarded as combined group.A double antibody sandwich enzyme-linked immunosorbent assay(ELISA)was tested the level of ADPN,Omentin,Leptin in blood serum of the subjects.Automatic blood biochemical analyzer was used respectively to detect the contents of fasting serum glucose(FPG),total cholesterol (TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C), turbidimetric immunoassay was used to detect the contents of glycosylated hemoglobin(HbAlc)and chemiluminescence was used to detect the contents of fasting serum insulin(FINS)of the subjects,and IR index was estimated by homeostasis model assessment.Result:The levels of serum Adiponectin,Omentin in CHD group and combined group were significantly lower than those in control group(F=45.75,113.12,q=8.23-19.65,P<0.01),the above indexes in combined group were significantly lower than those in CHD group(F=54.63,103.56,q=9.26,13.28,P<0.01),the levels of serum Leptin in CHD group and combined group were significantly higher than those in control group(F=35.36, q=9.12,12.34,P<0.01),the level of serum Leptin in combined group was significantly higher than that in CHD group (F=52.47,q=10.42,P<0.01).The adiponectin,leptin and omentin in each group associated with HOMA-IR were correlated(P<0.01).Conclusion:Adiponectin,Omentin and Leptin are risk factors for coronary artery heart.关键词
冠状动脉硬化性心脏病/2型糖尿病/脂联素/网膜素/瘦素Key words
Coronary artery heart/Type 2 diabetes mellitus/Adiponectin/Omentin/Leptin
