中国医学创新Issue(29)：66-68,69,4.DOI:10.3969/j.issn.1674-4985.2014.29.024
抗结核药物致肝损害的相关因素分析
Analysis of Related Factors of Liver Damage Caused by Anti Tuberculosis Drugs
陈雨燕 1李丹 1林秀华 1陈晓红 1林剑东 1刘建清1
作者信息
- 1. 福建医科大学教学医院福州肺科医院 福建 福州 350008
- 折叠
摘要
Abstract
Objective:To investigate the related factors liver damage caused by anti tuberculosis drugs. Method:The clinical data of 1538 tuberculosis patients in our hospital from January 2010 to August 2013 were retrospectively analyzed,the factors of liver damage caused by anti tuberculosis drugs were analyzed,including gender, age,race,diabetes history,drinking history,HbsAg,tuberculosis type and hepatitis history etc of patients. Result:In 1538 patients,the occurrence of mild liver injury in 154 cases(10.01%),45 cases of moderate liver injury (2.93%),severe liver injury in 25 cases(1.63%),the total injury in 224 cases(14.56%).The probability of occurrence of liver injury in HBsAg positive patients was significantly higher than that of negative,the probability of occurrence of liver injury in patients with diabetes history and hepatitis history were significantly higher than those in patients with no diabetes history and hepatitis history,the probability of occurrence of drug-induced liver injury in patients with drinking history was significantly higher than that in patients with no drinking history,prevalence rate of liver patients with preventive treatment was significantly lower than not treated patients,there was a relationship between risk and nutritional status of the patients with good or bad,the differences were statistically significant(P<0.05).Conclusion:When the treatment with anti-tb drugs,we should fully understand the patient’s condition,history,etc,choose less harmful anti-tb drugs to patients,and take the appropriate measures to the occurrence of liver protecting,as far as possible to reduce drug-induced liver injury,guarantee the anti tuberculosis therapy smoothly.关键词
抗结核药物/肝损害/危险因素/肺结核Key words
Anti-tuberculosis drugs/Liver damage/Risk factor/Pulmonary tuberculosis引用本文复制引用
陈雨燕,李丹,林秀华,陈晓红,林剑东,刘建清..抗结核药物致肝损害的相关因素分析[J].中国医学创新,2014,(29):66-68,69,4.
