中国医学创新Issue(34)：16-19,4.DOI:10.3969/j.issn.1674-4985.2014.34.005
双歧杆菌Ⅱ型毒素-抗毒素系统-MazEF的分子进化分析
The Molecular Evolution of Type Ⅱ Toxin-antitoxin(TA)System-MazEF in Bifidobacterial Genomes
摘要
Abstract
Objective:To perform molecular evolution analysis of MazEF in genomes of Bifidobacterium. Method:The Protein sequences of MazF in bifidobacterial genomes were obtained by employing the PSI-BLAST search from NCBI. The Protein sequences of MazF encoded by other bacteria were obtained from non-redundant protein database of NCBI. All of the 16 S rRNA sequences used in this study were obtained from non-redundant nucleotide database of NCBI. Clustal χ² and MEGA4 were used to analyze molecular evolution of MazF. Result:The total number of MazF in bifidobacterial genomes were searched of 26 The molecular evolution analysis showed that MazF in bifidobacterial genomes had less conservation;the co-evolution of MazF with the 16 S RNA was only observed in individual species and most homologous analysis results of MazF were not in concordance with 16 S rRNA. Conclusion:MazEF was integrated in bifidobacterial chromosomes through horizontal transfer,which was a part of the non-core genome.关键词
MazEF/毒素-抗毒素系统/分子进化/双歧杆菌Key words
MazEF/Toxin-antitoxin system/Molecular evolution/Bifidobacterium引用本文复制引用
韦艳霞,刘佃滨,郑纪伟,尤红娟,张鹏,李阳,汤仁仙..双歧杆菌Ⅱ型毒素-抗毒素系统-MazEF的分子进化分析[J].中国医学创新,2014,(34):16-19,4.基金项目
国家自然科学基金（31300029）；江苏省自然科学基金（BK20130213）；江苏省高校自然科学基金项目 （）
