中国医学创新Issue(35)：6-9,4.DOI:10.3969/j.issn.1674-4985.2014.35.003
不同血液净化方式对维持性血液透析患者微炎症状况及生存质量的影响
Effect of Different Blood Purification Methods on Micro-inflammatory State and the Quality of Life in Maintenance Hemodialysis Patients
摘要
Abstract
Objective:To investigate effect of different blood purification methods on micro-inflammatory state and the quality of life in maintenance hemodialysis patients.Method:A total of 75 MHD patients in the blood purification division of the dongguan people’s hospital were randomly divided into three groups:low flux hemodialysis group(HD group,n=25),hemodiafiltration group(HDF group,n=25)and hemodialysis combined hemoperfusion group(HD+HP group,n=25).The treatments lasted 6 months.The serum C-reactive protein(CRP),interleukin-6 (IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),hemoglobin(Hb)and serum albumin (ALB)were determined before and after the treatments in the there groups.The quality of life was evaluated using SF-36 questionaire.Result:After treatment,compared with HD groups,HDF group and HD+HP group had significantly lower levels of CRP,IL-6,IL-8,TNF-a,Ab and Hb were significantly better than before treatment(P<0.05),there were no difference between HDF group and HD+HP group.Total health condition,bodily pain,role-physical,social functioning,vitality and mental health in HDF group and HD+HP group were superior to those in HD group(P<0.05), there were no difference between HDF group and HD+HP group.But the difference was insignificant in role-emotional between three groups(P>0.05).Conclusion:Microinflammation state exists in MHD patients .HDF and HD+HP could had better effect than the HD on clearance of micro-inflammatory factor,may significantly improve the quality of life of MHD patients.关键词
血液透析/血液透析滤过/血液灌流/维持性血液透析/微炎症状态/生存质量Key words
Hemodialysis/Hemodiafiltration/Hemoperfusion/Maintenance hemodialysis patient/Micro-inflammatory state/Quality of life引用本文复制引用
胡浩强,周红梅,刘国辉..不同血液净化方式对维持性血液透析患者微炎症状况及生存质量的影响[J].中国医学创新,2014,(35):6-9,4.基金项目
东莞市科技计划一般项目 （）
