摘要
Abstract
Objective:To observe and compare the effect of induction chemotherapy with Paclitaxel and Nedaplatin combined with concurrent chemoradiotherapy and alone aoncurrent chemoradiotherapy in treatment of advanced nasopharyngeal carcinoma.Method:100 cases of advanced nasopharyngeal carcinoma patients were selected from our hospital from February 2013 to March 2014,and they were randomly divided into two groups,one was control group and the other was experiment group,the control group was treated by alone concurrent chemoradiotherapy,the experiment group were treated by induction chemotherapy with Paclitaxel and Nedaplatin combined with concurrent chemoradiotherapy,and then we compared the two groups of patients’s tumor control results.Result:In total efficacy rate,the experiment group was 96.00%,and the control group was 70.00%,the difference was significant(P<0.05). In treatment security,there were 2 cases with adverse reactions in control group,and there were 1 cases with adverse reactions in experiment group,the difference was not significant(P>0.05).Observation group 1 and 2 years after local regional control rate,distant metastasis-free survival rates were higher in both groups 1 and 2-year survival difference was not statistically significant.Conclusion:Induction chemotherapy combined with concurrent chemoradiotherapy has a good effect in treatment of advanced nasopharyngeal carcinoma,the whole treatment process is safe and reliable,and also patients and family members satisfy for the treatment,so it is worth to promote in clinical.关键词
晚期鼻咽癌/紫杉醇和奈达铂诱导化疗/放化疗Key words
Advanced nasopharyngeal carcinoma/Induction chemotherapy with Paclitaxel and Nedaplatin/Chemoradiotherapy
