中国医学创新Issue(36)：1-3,3.DOI:10.3969/j.issn.1674-4985.2014.36.001
老年糖尿病患者非酶糖基化与左室舒张功能的相关性
Relevance of Non-Enzymatic Glycosylation with Left Ventricular Diastolic Function in Elderly Patients with Type 2 Diabetes
摘要
Abstract
Objective:To observe the relevance of serum carboxymethyl with arterial stiffness and left ventricular diastolic function in elderly patients with type 2 diabetes.Method:116 elderly patients with type 2 diabetes from December 2013 to August 2014 in our hospital, and ELISA was applied to measure serum CML. The maximal velocity of mitral flow E peak and A were tested by two-dimensional echocardiography. The maximal speed of mitral flow E’ was measured by tissue Doppler.The E/A and E/E’ were calculated. The pulse wave velocity(PWV) was measured by Auto-survey atherosclerosis apparatus.Result:CML and age were positively correlated to baPWV and E/E’ by the univariate analysis (P<0.05). CML and age were negatively correlated to E/A(P<0.05).The multiple regression analysis showed CML was positively correlated to baPWV and E/E’ (P<0.01),while it was negatively correlated to E/A(P<0.01).Conclusion:CML is associated with increased arterial stiffness and decreased diastolic function in elderly patients with type 2 Diabetes. An treatment to decreasing advanced glycation end-product(AGEs)may be used to lower arterial stiffness and improve diastolic function.pulse wave velocity(PWV).关键词
左室舒张功能/羧甲基赖氨酸/非酶糖基化Key words
Left ventricular diastolic function/Serum carboxymethyl/Non-enzymatic glycosylation引用本文复制引用
卢妙,洪牮,王森..老年糖尿病患者非酶糖基化与左室舒张功能的相关性[J].中国医学创新,2014,(36):1-3,3.基金项目
国家自然科学基金青年基金资助 （）
