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依达拉奉对小鼠脑损伤后脑功能的保护机理

高占良 王合金 何建凡 阳书坤

中国医学创新Issue(36):16-17,18,3.
中国医学创新Issue(36):16-17,18,3.DOI:10.3969/j.issn.1674-4985.2014.36.006

依达拉奉对小鼠脑损伤后脑功能的保护机理

Edaravone Protection Mechanisms of Brain Injury in Mice Brain Function

高占良 1王合金 2何建凡 3阳书坤2

作者信息

  • 1. 广东省深圳市人民医院 广东 深圳 518000
  • 2. 广东省深圳市龙岗区人民医院
  • 3. 广东省深圳市疾病与预防控制中心
  • 折叠

摘要

Abstract

Objective:To explore the protection mechanism and application of the edaravone in the related brain function of the mice, after whose brain was injured.Method:40 healthy mice were maed into brain injure model and divided into experimental group and control group, each group 20, experimental group were given edaravone treatment, control group given the same amount of saline.SOD and MAD of two gruoups were measured and compared. Result:The experimental group’s body indexes were better than the control group, the difference was significant (P<0.05); the experiment group’s of SOD, MAD and S-100 protein index were better than the control group, the difference was significant (P<0.05).Conclusion:Edaravone have a large role in protecting mouse brain function and avoiding brain injure,worthy of clinical application.

关键词

依达拉奉/脑损伤/脑功能/保护机理

Key words

Edaravone/Brain injure/Brain function/Protection mechanism First-author’s address:Shenzhen People’s Hospital,Shenzhen 518000,China

引用本文复制引用

高占良,王合金,何建凡,阳书坤..依达拉奉对小鼠脑损伤后脑功能的保护机理[J].中国医学创新,2014,(36):16-17,18,3.

基金项目

深圳市科技计划项目 ()

中国医学创新

1674-4985

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