中国医学创新Issue(3)：10-12,3.DOI:10.3969/j.issn.1674-4985.2015.03.004
中重型颅脑损伤脑脊液和血清S100B蛋白水平时间相关性研究
The Time Correlation of Cerebrospinal Fluid and Serum S100B Levels in Moderate and Severe Traumatic Brain
摘要
Abstract
Objective:To detect the S100B protein change levels in cerebrospinal fluid(Cerebrospinal fluid, CSF) and serum after moderate and severe craniocerebral injury to study the time correlation of levels in cerebrospinal fluid and serum.Method:48 cases were selected as the control group, the levels of S100B protein in serum and cerebrospinal fluid were determined. 96 patients with moderate and severe craniocerebral injury (GCS 6-12 scores) were selected, their serum and cerebrospinal fluid were collected and the concentration of S100B protein,1,3,5,7,14,21 d respectively after injury were detected.Result:After moderate and severe craniocerebral injury,the levels of S100B protein in the serum and Cerebrospinal fluid of patients changed with time. The peaks of S100B protein in CSF and serum were both occurrrd at the first day and the third day after injury, CSF and serum S100B protein levels were higher than control group , the difference was statistically significant(P<0.05) at each time points, the S100B protein levels in CSF and serum existed a certain correlation after a period time of injury.Conclusion:The levels of S100B protein in cerebrospinal fluid and serum are closely related with each other, but this correlation gradually reduced as the time gone by.关键词
颅脑损伤/血清/脑脊液/S100B蛋白Key words
Craniocerebral injury/Serum/Cerebrospinal fluid/S100B protein引用本文复制引用
李鹏林,张强..中重型颅脑损伤脑脊液和血清S100B蛋白水平时间相关性研究[J].中国医学创新,2015,(3):10-12,3.基金项目
青海省自然科学基金项目 （）
