中国医学创新Issue(3)：143-146,4.DOI:10.3969/j.issn.1674-4985.2015.03.049
DNA双链断裂与同源重组修复的研究进展
Advance in Research of Homologous Recombination Repair in DNA Double Strands Breakage
摘要
Abstract
DNA double strand breakage (DSB) is the most significantly biological effect when cells are exposed to ionizing radiation (IR) which may result in apoptosis, checkpoint arrest, cellular senescence and DSB repair. DNA damage response (DDR) is activated with induction of DNA damage. The mechanisms involved in DSB repair include homologous recombination (HR) and non-homologous end-joining (NHEJ). HR, a template-dependent and mostly error-free pathway, plays a crucial role in protecting genome fidelity from DSB. It can be divided into three phases including presynaptic, synaptic and postsynaptic phases. For the repair of DSBs caused by IR, HR is mainly restricted in G2 and S phases while NHEJ and HR function complementarily. HR is related to the risk of tumorigenesis, predicts the survival of several kinds of carcinoma and is a novel target of cancer therapy. This article has comprehensively reviewed the progress in understanding of the mechanism of HR repair, its associated factors affecting the fidelity in DSB repair, the concept of synthetic lethality and its association with NHEJ repair. The potential of its clinical application by targeting specific DSB repair pathways is further explored.关键词
DNA双链断裂/同源重组/非同源末端连接/合成致死/转化医学研究Key words
DNA double strands breakage/Homologous recombination/Non-homologous end-Joining/Synthetic lethality/Translational medical research引用本文复制引用
董隽,张天,碧秀..DNA双链断裂与同源重组修复的研究进展[J].中国医学创新,2015,(3):143-146,4.基金项目
国家自然科学基金项目（81172209）；广东省自然科学基金项目 （）
