中国医学创新Issue(7)：4-6,3.DOI:10.3969/j.issn.1674-4985.2015.07.002
NF-κB与早发型及晚发型子痫前期的相关性研究
The Relationship Study of NF-κB with Early-onset and Late-onset Preeclampsia
淦蓓1
作者信息
- 1. 福建医科大学附属第一医院 福建 福州 350005
- 折叠
摘要
Abstract
Objective: To explore the relationship of NF-κB in placenta with early-onset (gestational age <32 weeks)and late-onset(gestational age ≥32 weeks)preeclampsia.Method:40 PE women were selected and divided into early-onset PE group of 20 cases and late-onset PE group of 20 cases.The normal control group were 30 healthy normotensive pregnancy.Immunohistochemistry was employed to show the location distribution and quantity of NF-κBp65 in placenta of preeclampsia.Result:NF–κBp65 in placenta of preeclampsia was stronger expression than that of control group,and was stronger expression in early-onset preeclampsia than that in late-onset preeclampsia,the differences were statistically significant(P<0.05).Conclusion: It suggests that NF–κB participate in the pathogenesis of preeclampsia.Increasing NF–κB activity in placenta induces the immune inflammatory reaction,which may be related to the etiology of early-onset and late-onset preeclampsia.关键词
早发型及晚发型子痫前期/核因子-κB/胎盘Key words
Early-onset and late-onset preeclampsia/NF-κB/Placenta引用本文复制引用
淦蓓..NF-κB与早发型及晚发型子痫前期的相关性研究[J].中国医学创新,2015,(7):4-6,3.
