中国医学创新Issue(7)：14-17,4.DOI:10.3969/j.issn.1674-4985.2015.07.005
一种新的大鼠脊髓半离断损伤模型
New Model for Lateral Lumbar Spinal Cord Injury in Rats
摘要
Abstract
Objective:To investigate a lateral spinal cord injury model with less trauma and better replication. The model would be usefull for the study of various new medicines or stem cell therapy on spinal cord injury.Method: A modified self-made needle was used to insert into lumbar spinal cord of SD rats without opening the cavum medullare,the lateral spinal cord injury was established.The grasping ability (movement function) and sensory function by temprature of hind-limbs were measured and compared with contralateral side at different time points after injury for insure the model was successfully.Result:It showed that lateral spinal cord injury model of rats appeared obvious lateral paralysis ,but without incontinence of urine and defecation. Also none of them had infection locally or systemically. The model was successfully.Conclusion:The spinal injure model made by self-made modified needle insertion into SD rats lumbar spinal cord is easy to handle ,repeat,and induce obvious lateral paralysis without severe complications.Due to its advantage of connecting, some medicines or stem cells could be injected conveniently at the same time while surgery processed,then provides an experimental basis to explore the molecular mechanism of spinal cord injury regeneration difficulty.关键词
SD大鼠/脊髓损伤/脊髓半离断术Key words
Sprague Dawley rat/Spinal cord injury/Spinal lateral amputation引用本文复制引用
齐超,李夏青,张宏..一种新的大鼠脊髓半离断损伤模型[J].中国医学创新,2015,(7):14-17,4.基金项目
国家自然科学基金面上项目（81171178）；山西省自然科学基金项目（2012011036-3）；山西省留学人员科研资助项目 （）
