中国医学创新Issue(8)：13-15,3.DOI:10.3969/j.issn.1674-4985.2015.08.005
舒芬太尼后处理对大鼠肝缺血再灌注肾损伤的影响
Effects of Sufentanil Post-conditioning on Renal Injury Induced by Hepatic Ischemia-reperfusion in Rats
李敏 1武莉 1刘臻 1曹定睿2
作者信息
- 1. 山西医科大学 山西 太原 030001
- 2. 山西医科大学第一医院
- 折叠
摘要
Abstract
Objective:To investigate the effects of Sufentanil post-conditioning on renal injury induced by hepatic ischemia-reperfusion in rats.Method:Fifty-four Wista rats were randomly allocated into three groups(n=18):Sham operation group(S group),hepatic ischemia-reperfusion group(I/R group)and Sufentanil post-conditioning group(SP group).The rats were killed at the same time to obtain the renal tissue and take blood from the heart after hepatic ischemia 1 hour reperfusion for 2,4 and 6 hours,then tested cystatinC(CysC),observed the pathological changes in renal tissue,detected the expression of Bcl-2 and Bax proteins in kindy by immunohistochemistry and the apoptosis index(AI) of the renal cells was observed by Tunel method.Result:Compared with the S group,CysC,AI and the expression of Bcl-2 and Bax proteins incresed in I/R group and SP group.Compared with the I/R group,CysC,AI and the expression of Bax protein decresed but the expression of Bcl-2 protein incresed in SP group.Conclusion:The protective effects of Sufentanil post-conditioning on renal injury induced by hepatic ischemia-reperfusion in rats may be related to the decresed expression of Bax protein and the incresed expression of Bcl-2 protein.关键词
肝缺血再灌注/肾损伤/舒芬太尼Key words
Hepatic ischemia-reperfusion/Renal injury/Sufentanil引用本文复制引用
李敏,武莉,刘臻,曹定睿..舒芬太尼后处理对大鼠肝缺血再灌注肾损伤的影响[J].中国医学创新,2015,(8):13-15,3.
