摘要
Abstract
Objective:To explore the prevalence and study the clinic significance of autoimmune liver disease-related antibodies in patients with primary biliary cirrhoses(PBC).Method:The anti-AMA in 61 PBC(PBC group), 50 AIH(AIH group)and 52 other liver diseases(control group)were detected by IIF.Anti-AMA-M2,anti-GP210, anti-SP100,anti-SLA,anti-LC1 and anti-LKM-1 antibodies were measured by ELISA.Result:The positive rates of anti-AMA,anti-AMA-M2,anti-GP210,anti-SP100,anti-LC1,anti-SIA and anti-LKM-1 antibodies were 91.8%(56/61),86.9%(53/61),36.1%(22/61),24.6%(15/61),1.6%(1/61),0(0/61)and 1.6%(1/61)in PBC group;18.0%(9/50),6.0%(3/50),8.0%(4/50),14.0%(7/50),0(0/50),6.0%(3/50)and 4.0%(2/50) in AIH group;5.8%(3/52),1.9%(1/52),5.8%(3/52),11.5%(6/52),0(0/52),0(0/52)and 0(0/52) respectively in control group.Anti-AMA,anti-AMA M2 and anti-GP210 were detected more frequently in PBC group than AIH group(P<0.01),while anti-SLA was detected more frequently in AIH group than PBC group(P<0.01). Conclusion:Anti-LC1,anti-SLA and anti-LKM-1 antibodies in PBC and AIH were detected at a very low frequency in the corhort.There was little significance for screening anti-LC1,anti-SLA,anti-LKM-1 antibodies in patients with autoimmune liver diseases.It is of importance to detect anti-AMA and anti-GP210 antibodies for diagnosis of PBC.关键词
原发性胆汁性肝硬化/自身免疫性肝炎/自身抗体Key words
Biliary liver cirrhosis/Autoimmune hepatitis/Autoantibodies
