中国医学创新Issue(11)：5-7,3.DOI:10.3969/j.issn.1674-4985.2015.11.002
IHC与FISH检测118例乳腺浸润性导管癌HER-2的对比分析
The HER-2 Contrast Analysis on 118 Cases with Breast Invasive Ductal Carcinoma by IHC and FISH Detection
摘要
Abstract
Objective:To compare the consistency of HER-2 in breast infiltrating ductal carcinoma by IHC and FISH detection.Method:HER-2 of 118 cases with breast invasive ductal carcinoma were tested by FISH and IHC detection,and compared the results correlation.Result:118 specimens of invasive ductal carcinoma were seleced,The results tested by IHC were as follows:14 cases(-);20 cases(1+),55 cases(2+),29 cases(3+).The results tested by FISH were as follows:53 cases>2.2,64 cases<1.8,1 case was 1.8-2.2.HER-2 positive coincidence rate was 96.6%(28/29)by IHC detection in positive cases by FISH detection,HER-2 negative by FISH were in negative of IHC detection,the coincidence rate was 100%(34/34).25 HER-2 positive cases by FISH detection were among 55 cases of HER-2(2+)by IHC detection,and 30 were the negative.5 cases on chromosome multi-body in 17 were found by FISH detection,its incidence rate was 4.24%.HER-2 expression in 8 cases with of breast cancer exists heterogeneity by IHC detection,and the heterogeneity was also confirmed in FISH detected.Conclusion:HER-2 of breast infiltrating ductal carcinoma by IHC detection was high consistency with FISH detection,HER-2 cases(2+)by immunohistochemical need to be detected by FISH.关键词
浸润性导管癌/HER-2/免疫组织化学/荧光原位杂交Key words
Infiltrating ductal carcinoma/HER-2/Immunohistochemistry/Fluorescence in situ hybridization引用本文复制引用
朱文标,郑少秋,卢善明,谢寿城..IHC与FISH检测118例乳腺浸润性导管癌HER-2的对比分析[J].中国医学创新,2015,(11):5-7,3.基金项目
梅州市科技计划项目 （）
