中国医学创新Issue(12)：14-17,4.DOI:10.3969/j.issn.1674-4985.2015.12.005
云南汉族人群CTLA-4基因多态性与自身免疫性甲状腺疾病的关系
Relationship between T-lymphocyte-associated antigen-4 Gene Polymorphism in Yunnan Han Population and Autoimmune Thyroid Disease
摘要
Abstract
Objective:To investigate the correlation of gene polymorphism Cytotoxic T lymphocyteassociated Antigen4 (CTLA-4)at position 49 in exon 1 codon 17 with autoimmune thyroid disease (AITD).Method:The gene polymorphism CTLA-4 at position 49 in exon 1 codon 17 were conducted using polymerase chain reaction with sequence specific primers in the specimen of peripheral blood.82 patients with Graves disease (GD) and 51 patients with Hashimoto’s thyroiditis (HT) were recruited.80 healthy volunteers constituted the control group.Result:The gene frequencies of CTLA-4 at position 49 in exon 1 codon 17 GG genotype and G alleles were significantly higher in GD groupthan in control group( χ2=9.353,P=0.009; χ2=7.548,P=0.006).The gene frequencies of CTLA-4 at position 49 in exon 1 codon 17 GG genotype and G alleles were not significantly different in HT group and control group( χ2=0.062, P=0.969; χ2=0.046,P=0.830).Conclusion:The gene polymorphism CTLA-4 at position 49 in exon 1 codon 17 may be an independent risk factor for AITD.关键词
自身免疫性甲状腺疾病/细胞毒性T淋巴细胞相关抗原4/基因多态性Key words
Autoimmune thyroid disease/Cytotoxic T lymphocyteassociated antigen 4/Gene polymorphism引用本文复制引用
王毅鹏,彭葆坤,朱丽芹,翁晓春,王瑛,唐哲..云南汉族人群CTLA-4基因多态性与自身免疫性甲状腺疾病的关系[J].中国医学创新,2015,(12):14-17,4.基金项目
国家自然科学基金（地区科学基金项目） （）
