中国医学创新Issue(12)：26-29,30,5.DOI:10.3969/j.issn.1674-4985.2015.12.008
辣椒素受体在大鼠坐骨神经损伤再生过程中的作用研究
The Effect of Transient Receptor Potential Vanilloid 1 on the Axonal Regeneration after Sciatic Crush Injury in Rats
摘要
Abstract
Objective:To observe the effect of the transient receptor potential vanilloid 1 (TRPV1) on neuronal regeneration after crush injury to the rat’s sciatic nerve.Method:The right sciatic nerve of the adult male Sprague-Dawley rats were crushed.Rats in the experimental group received a subcutaneous injection of AMG-517 ,a highly potent and selective TRPV1 antagonist, into the right hind paw 1 h before the crush.At the crush zone, proximal zone and distal zone, the numbers of myelinated fibers on the transverse section were counted after a surviving time of 7 or 14 days. Result:(1)At the intact side and the proximal zone,the numbers of myelinated fibers did not show any difference. (2) the sciatic nerve injury in the middle of neural axon number counting found that damage to 1 week compared with in 2 weeks, AMG517 treatment+1 week after injury compared with 2 weeks, pure injury and compared between AMG517 + damage, its axon number difference had statistical significance (P<0.01).Use AMG517 treatment group rats sciatic nerve injury of axon number significantly more than the simple injury group.(3) In the distal sciatic nerve injury, the nerve axon number of damage extended axon number increased with time, especially the damage before used AMG517 treatment group rats damage distal nerve axon number increased obviously, the difference was statistically significant (P<0.01). Conclusion:Blockage of the TRPV1 can promote neuronal regeneration after sciatic crush injury.关键词
辣椒素受体/瞬时受体电位香草酸受体1/神经损伤与再生Key words
Capsaicin receptor/TRPV1/Nerve injury and regeneration引用本文复制引用
张宏,齐超,钱贝,刘俊肖,张华,乔晓玲,李夏青..辣椒素受体在大鼠坐骨神经损伤再生过程中的作用研究[J].中国医学创新,2015,(12):26-29,30,5.基金项目
国家自然科学基金面上项目（81171178）；山西省自然科学基金项目（2012011036-3）；山西省归国人员科研资助项目 （）
