摘要
Abstract
Objective:To Observe the effects of irbesartan on carotid intima-media thickness and clinical biochemical indexes of patients with early diabetic nephropathy.Method:86 patients with early DN normotensive were randomly divided into irbesartan group(E group) and perindopril group(P group),43 cases in each group.Both groups were given conventional treatment such as diet control and lower blood sugar.Patients in the P group were given perindopril tablets 4 mg/d,1 time/d, while the E group was given irbesartan tablets 0.15 g/d,1 time/d,the treatment continued for 48 weeks.Urinary albumin excretion rate(UAER),changes in plasma Hcy level and carotid IMT before and after treatment were compared between the two groups. Result:After treatment,the UAER,plasma Hcy level、SBP、DBP and carotid IMT of the two groups were significantly lower than before treatment(P<0.05).Carotid IMT had a positive correlation with UAER and Hcy(P<0.01).Conclusion:UAER and Hcy of patients with early diabetic have a positive correlation with carotid IMT,There is a close relationship between diabetic microvascular lesion and macrovascular complication.Irbesartan can reduce early DN patients’SBP,DBP,UAER,Hcy and IMT,it has a practical significance in delaying early DN patients’ major complications.关键词
厄贝沙坦/糖尿病肾病/尿清蛋白排泄率/同型半胱氨酸/颈动脉内膜中层厚度Key words
Irbesartan/Diabetic nephropathy/Urinary albumin excretion rate/Homocysteine/Carotid intima-media thickness
