中国医学创新Issue(20)：6-8,9,4.DOI:10.3969/j.issn.1674-4985.2015.20.002
急性期精神分裂症5-HT转运体mRNA表达研究
The Expression Levels Study of Serotonin Transporter mRNA in the Acute Phase of Schizophrenia
摘要
Abstract
Objective: To study the differences of serotonin transporter (SERT)mRNA expression levels in peripheral leukocytes between acute phase of schizophrenia patients and healthy control. To study the gender differences in the SERT mRNA expression levels between two groups.Method: 44 patients with acute phase of schizophrenia were selected in our hospital from May 2013 to November 2013, and then 42 healthy cases with the same age and gender were selected as the control group. The diagnosis of schizophrenia was established according to the DSM-IV-TR criteria. The severity of schizophrenia was assessed by the positive and negative syndromes scales(PANSS).All subjects were interviewed using self-designed questionnaire on general information and tested by quantitative real-time PCR method in SERT mRNA levels.Result:SERT mRNA levels in leukocytes in acute phase of schizophrenia patients were significantly higher than that in control group,the difference was statistically significant (P<0.05).Compared the SERT mRNA levels of two groups’gender, the difference was no statistically significant(P>0.05). Conclusion: The over expression of SERT mRNA levels may be one of the biomarkers of schizophrenia in acute phase.关键词
精神分裂症/5-HT转运体/mRNA表达/RT-PCRKey words
Schizophrenia/Serotonin transporter/mRNA expression/RT-PCR引用本文复制引用
胡昌清,杨杨,陈静,丰雷,史晓宁,田腾飞,甄龙,王刚..急性期精神分裂症5-HT转运体mRNA表达研究[J].中国医学创新,2015,(20):6-8,9,4.基金项目
重大新药创制科技重大专项（2012ZX09303014-002）；国家自然科学基金面上项目（81171269）；北京市教委面上项目 （）
