中国医学创新Issue(21)：19-20,21,3.DOI:10.3969/j.issn.1674-4985.2015.21.007
基因修饰的骨髓间充质干细胞移植对大鼠急性心肌梗死的疗效观察
The Curative Effect Observation of Gene Modified Bone Marrow Mesenchymal Stem Cells Transplantation on Acute Myocardial Infarction in Rats
摘要
Abstract
Objective:To explore the curative effect observe of gene modified bone marrow mesenchymal stem cells transplantation on acute myocardial infarction in rats.Method: 20 SD rats of 15 day old were selected and divided into two groups, the observation group (vascular endothelial growth factor group) and control group (DMEM group), 10 rats in each group, the preparation of acute myocardial infarction model, the observation group rats underwent gene modified bone marrow mesenchymal stem cells transplantation,the control group rats were injected with serum free DMEM, after one month transplantation,the cardiac function of two groups were observed.Result: The observation group and the control group LVEF rats were respectively (73.45±9.17)% and (43.26±6.33)%, the observation group was significantly higher than that in the control group, the difference was statistically significant(P<0.05);two groups of rats were found with microscope in the formation of left ventricular scar tissue,with angiogenesis and the emergence of remodeling left ventricular, compared with the control group,the observation group rats heart changed significantly; the observation group and the control group of rats with vascular density of rats were respectively (45.69±4.28) and (17.41±3.67), the observation group was significantly higher than that in the control group, the difference was statistically significant(P<0.05).Conclusion: Vascular endothelial growth factor gene modified bone marrow mesenchymal stem cells transplantation has good therapeutic effect on acute myocardial ischemia in rats.关键词
骨髓间充质干细胞/心肌梗死/大鼠Key words
Bone marrow mesenchymal stem cell/Myocardial infarction/Rat引用本文复制引用
熊永泉,陆东风,何志裕..基因修饰的骨髓间充质干细胞移植对大鼠急性心肌梗死的疗效观察[J].中国医学创新,2015,(21):19-20,21,3.基金项目
国家医学教育发展中心 （）
