中国医学前沿杂志（电子版）Issue(5)：42-44,3.
白细胞介素17在早期类风湿关节炎患者血清和滑膜液中的表达研究
The study of the expression of interleukin17 in serum and synovial lfuid of rheumatoid arthritis patients
摘要
Abstract
ObjectiveTo study the expression and clinical signiifcance of interleukin17 (IL-17) in serum and synovial lfuid samples of patients with rheumatoid arthritis (RA).MethodsThe serum and synovial lfuid samples of untreated patients with rheumatoid arthritis from our hospital during June 2012 and June 2013 were collected, and patients with osteoarthritis (OA) were included as controls. A total of 30 eligible RA patients and 30 age and sex-matched patients with osteoarthritis were included. And the expression of IL-17 in serum and synovial lfuid samples were examined by enzyme-linked immunosorbent assay, and the correlation of IL-17 levels with high-sensitivity C-reactive protein (hs-CRP), rheumatoid factor (RF) and disease activity score DAS28 were also analyzed.ResultsIn this cohort, serum IL-17 levels were signiifcantly higher in RA patients than OA patients [(289.5±103.2) ng/L∶(86.4±30.3) pg/ml,P<0.05], and the levels of IL-17 in synovial lfuids were also signiifcantly higher in RA patients than OA patients [(336.4±105.3) pg/ml∶(95.7±22.5) pg/ml, P<0.05]. In RA patients, the levels of serum hs-CRP and RF were (44.6±12.3) mg/L and (215.7±56.2) U/L, respectively; and DAS28 score was (5.6±1.5). And linear regression analysis showed that IL-17 levels in serum and synovial lfuid were both positively correlated with serum hs-CRP, RF and DAS28 score in RA patients (P<0.05).ConclusionIL-17 levels are signiifcantly higher in serum and synovial lfuid of RA patients, and IL-17 would be used as an indicator for monitoring the disease activity of RA.关键词
类风湿关节炎/白细胞介素17/血清/滑膜液/病情活动Key words
Rheumatoid arthritis/Interleukin-17/Serum/Synovial lfuid/Disease activity引用本文复制引用
程佳,张晶..白细胞介素17在早期类风湿关节炎患者血清和滑膜液中的表达研究[J].中国医学前沿杂志（电子版）,2014,(5):42-44,3.基金项目
四川省卫生厅科研课题 （）
