中国医学前沿杂志（电子版）Issue(6)：91-93,3.
血栓弹力图检测国产氯吡格雷和进口氯吡格雷对急性冠状动脉综合征患者血小板抑制情况分析
Thromboelastography detection analysis of platelet inhibition effects between domestic and imported clopidogrel in acute coronary syndrome patients
高筱红 1王立革 1赵慧慧 1许丁 1杨明 1李丽亚1
作者信息
- 1. 北京平谷区医院 心内科，北京 101200
- 折叠
摘要
Abstract
Objective To evaluate the effects between domestic clopidogrel with aspirin and inport clopidogrel with aspirin on platelet inhibition in acute coronary syndrome (ACS) patients by thrombelastograph. Method 204 ACS patients ift for dual antiplatelet therapy in hospital were randomly selected from July 2012 to July 2013, and they were randomly divided into domestic clopidogrel group (101 cases) and imported clopidogrel group (103 cases), the two groups of patients taking corresponding drugs for 5 ~ 7 days. Then, test the clot strength and platelet function of the whole blood by thrombelastograph. Result The baseline data and thrombelastogram (TEG) detection time between the two groups had no signiifcant differences. In the domestic clopidogrel group, TEG test results of blood cross-linked clot strength:(60.40±11.99) mm, the clot strength induced by adenosine diphosphate:(37.54±16.24) mm, the platelet inhibition rate of adenosine diphosphate pathways:(46.41±26.85)%, the clot strength induced by arachidonic acid:(31.81±16.06) mm, the platelet inhibition rate of arachidonic acid pathways:(56.18±28.29)%. In the imported clopidogrel group, TEG test results of blood cross-linked clot strength:(61.94±8.41) mm, the clot strength induced by adenosine diphosphate:(38.07±15.46) mm, the platelet inhibition rate of adenosine diphosphate pathways:(48.07±26.17)%, the clot strength induced by arachidonic acid:(31.94±15.81) mm, the platelet inhibition rate of arachidonic acid pathways:(58.25±27.38)%. Between the two groups, platelet inhibition function showed no difference, P>0.05. Conclusion After dual antiplatelet therapy in patients with ACS, the TEG detection results of antiplatelet effects between domestic clopidogrel with aspirin group and inport clopidogrel with aspirin group had no signiifcant difference.关键词
血栓弹力图/国产氯吡格雷/进口氯吡格雷/急性冠状动脉综合征/血小板抑制Key words
Thromboelastography/Domestic clopidogrel/Imported clopidogrel/Acute coronary syndrome/Platelet inhibition引用本文复制引用
高筱红,王立革,赵慧慧,许丁,杨明,李丽亚..血栓弹力图检测国产氯吡格雷和进口氯吡格雷对急性冠状动脉综合征患者血小板抑制情况分析[J].中国医学前沿杂志（电子版）,2014,(6):91-93,3.
