中国医学前沿杂志（电子版）Issue(9)：30-32,3.
黑龙江地区丙型病毒性肝炎病毒基因型与亚型的分布特点及临床意义
Distribution and clinical significance of genotypes and subtypes of hepatitis C virus in Heilongjiang province
摘要
Abstract
Objective To explore the distribution and clinical signiifcance of genotypes and subtypes of hepatitis C virus (HCV) in Heilongjiang province and provide basis for the clinical treatment and prognosis. Method HCV RNA was extracted and genotypes and subtypes was tested in serum samples that anti HCV antibody and HCV RNA were all positive. The basic information, route of infection, the result of liver function of patients was collected at the same time. Result The main hepatitis C virus (HCV) genotype in Hei-longjiang province was 1b type, accounted for 50.0%, and followed by 2a type. The genotyping constitute between different route of infection was no signiifcant difference. The genotyping constitute between different degree of disease was statistically significant. The content of HCV RNA and fatty degeneration rate of 1b type in patients with hepatitis C were higher than 2a type (Pal <0.05). Conclusion The HCV genotype of Heilongjiang province was 1b type and had diversity, the HCV genotypes and liver disease severity has certain relevance. The detection of genotype classiifcation has prediction effect for the progress and prognosis.关键词
丙型病毒性肝炎/肝炎病毒/基因型/亚型/黑龙江Key words
Viral hepatitis type C/Hepatitis C virus/Genotypes/Subtypes/Heilongjiang province引用本文复制引用
毕蔓茹,王晓韧,王威,陈立艳,颜炳柱,杨宝山..黑龙江地区丙型病毒性肝炎病毒基因型与亚型的分布特点及临床意义[J].中国医学前沿杂志（电子版）,2014,(9):30-32,3.基金项目
黑龙江省卫生厅课题（2009-144）；哈医大二院青年启动基金 （）
