摘要
Abstract
ObjectiveTo explore the correlation between changes in the expression level of macrophage migration inhibitory factor (MIF) and tumor necrosis factor-α (TNF-α) in type 2 diabetes patients and carotid atherosclerosis and diabetic nephropathy.Method90 patients with type 2 diabetes admitted into the department of endocrinology of our hospital from October 2011 to May 2013 were randomly selected, and they were divided into non carotid artery lesion group (54 patients) and carotid artery lesion group (44 patients) according to the existence of carotid artery, and 40 healthy person undergoing physical examination during the same period were separately selected. The blood lipid, renal function and other indexes of patients in three groups were determined, and the difference and correlation between MIF, TNF-α and carotid artery intima-media thickness (IMT) in three groups were compared and analyzed.ResultThe comparisons in levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) of patients in three groups were not signiifcantly different (P>0.05), and the comparisons in levels of fasting blood glucose (FPG), glycosylated hemoglobin (HbΑ1c), MIF, TNF-α, IMT, urinary albumin creatinine (Α/C) of patients in three groups were signiifcantly different (P<0.05). The levels of FPG, HbΑ1c, MIF, TNF-α, Α/C of patients in non-carotid artery disease group and carotid artery disease groups were signiifcantly higher than those of patients in control group (P<0.05), and the level of IMT in patients in carotid artery lesions group was signiifcantly higher than that of control group (P<0.05). The level of MIF was positively related to MIF and A/C (r=0.399,P=0.000;r=0.547,P=0.000), and the level of TNF-α was positively related to IMT and Α/C (r=0.340,P=0.001;r=0.383,P=0.000). ConclusionThe expression levels of MIF and TNF-α were signiifcant in diabetic patients with carotid artery disease, and they are slightly related to carotid atherosclerosis and diabetic nephropathy.关键词
巨噬细胞移动抑制因子/肿瘤坏死因子-α/2型糖尿病/糖尿病肾病/颈动脉粥样硬化Key words
Macrophage migration inhibitory factor/Tumor necrosis factor-α/Type 2 diabetes/Diabetic nephropathy/Carotid atherosclerosis
