中国医学前沿杂志（电子版）Issue(10)：159-162,4.
大肠癌组织中Galectin-3与MMP-2、TIMP-2的表达及临床意义
The expression and clinical signiifcance of Galectin3 and MMP2, TIMP2 in human colorectal carcinoma
李英健 1赵恩宏 1苏锐 1侯雷 1刘志满 1申兴斌2
作者信息
- 1. 承德医学院附属医院 胃肠外科，河北 承德067000
- 2. 承德医学院附属医院 病理科，河北 承德067000
- 折叠
摘要
Abstract
ObjectiveTo study the expression of Galectin-3 and MMP-2, TIMP-2 in colorectal carcinoma, and to investigate its in colorectal cancer progression of meaning in the course.MethodTo detect the expression of Galectin-3 and MMP-2,TIMP-2 in 52 cases of colorectal cancer, 20 cases of colorectal adenoma and 20 cases of colorectal normal mucosa tissue through the application of immunohistochemistry. Analyzed the relationship between its expression with the patient’s sex, age, tumor location, tumor differentiation, inifltration and lymph node metastasi.Result ①In colorectal carcinoma, the expression of Galectin-3 and MMP-2 were highest and the expression of TIMP-2 was lowest;②In inifltration over the muscle layer of the colorectal carcinoma and in poorly differentiated colorectal carcinoma and in lymph node metastasis of colorectal cancer tissues, the expression of Galectin-3 and MMP-2 were higher and the expression of TIMP-2 was lower;③The expression of Galectin-3 and MMP-2 were positive correlation and the expression of Galectin-3 and TIMP-2 were negative correlation in colorectal carcinoma.ConclusionThe imbalance expression of Galectin-3, MMP-2 and TIMP-2 is positive corrrelated with the invasion and metastasis of colorectal carcinoma.关键词
大肠癌/半乳糖凝集素-3/基质金属蛋白酶-2/组织基质金属蛋白酶抑制剂-2Key words
Colorectal carcinoma/Galectin-3/MMP-2/TIMP-2引用本文复制引用
李英健,赵恩宏,苏锐,侯雷,刘志满,申兴斌..大肠癌组织中Galectin-3与MMP-2、TIMP-2的表达及临床意义[J].中国医学前沿杂志（电子版）,2014,(10):159-162,4.
