摘要
Abstract
Objective To discuss the effect of seretide combined with tiotropium atomized inhalation for lung function on chronic obstructive pulmonary diseases (COPD). Method 96 patients with stable COPD were randomly divided into observation group and control group, 48 cases in each group. Control group were treated with salmeterol assigned powder inhaler, observation group based on control group, were treated with tiotropium bromide. Compared two groups before treatment and after treatment of 3 months of lung function, score of dyspneic respiration, adverse reactions. All patients were followed-up one year, compared the number of acute exacerbations of COPD between two groups. Result There was no signiifcantly difference in FVC, FEV1, and FEV1/FVC between two groups before treatment (P>0.05), after 3 months of treatment, FVC, FEV1, and FEV1/FVC were signiifcantly improved in two groups, and observation group were signiifcantly higher than control group (P<0.01);after 3 months of treatment in two groups of patients with dyspnea scores were signiifcantly decreased, and observation group lower than control group (P<0.01);adverse reactions during treatment in the patients of two groups had no signiifcant difference (P>0.05);during the 1 years of follow-up, patients in observation group COPD the number of acute attack was signiifcantly less than that of control group. Conclusion Salmeterol assigned powder inhaler combined with tiotropium bromide can effectively alleviate clinical symptoms and signs, improve the quality of life in patients with stable COPD, without serious adverse reactions or side effects, it’s safe and effective, worthy of promoting.关键词
沙美特罗替卡松粉吸入剂/噻托溴铵/慢性阻塞性肺疾病/肺功能Key words
Salmeterol assigned powder inhaler/Tiotropium bromide/COPD/Lung function
