摘要
Abstract
Objective To study relativity between ratio of urinary protein to creatinine (A/C) and activity of renin-angiotensinsystem on patients with type 2 diabetes melitus. Method 160 cases of patients with type 2 diabetes melitus were selected and divided into A/C normal group (96 cases) and A/C abnormal group (64 cases) according to weather with normal A/C, and 60 health volunteers were selected as control group, and all patients and voluntary were detected and contrasted with index of RAS between the three groups, then relativity between A/C and index of RAS were analysied with Logistic regression analysis. Result A/C abnormal group and A/C normal group patients with venous renin (PRA), angiotensinⅡ(AngⅡ) and aldosterone levels were higher than control group, A/C abnormal group vein blood of patients with PRA, AngⅡand aldosterone levels were higher than A/C normal group, the difference was signiifcant (P < 0.05). Logistic regression analysis showed no signiifcant correlation between the A/C and venous PRA (P>0.05), A/C and AngⅡ, aldosterone levels were positively correlated (r = 0.495, 0.316;P = 0.000, 0.002). Conclusion There is a relativity between A/C and activity of RAS on patients with type 2 diabetes melitus, activation of RAS maybe is a reason of renal and damage, and detecting A/C can relfect degree of RAS activation.关键词
尿白蛋白排泄率/肌酐/2型糖尿病/肾素-血管紧张素系统/血管紧张素Ⅱ/醛固酮Key words
A/C/Type 2 diabetes melitus/Renin-angiotensin system/AngiotensinⅡ/Aldosterone
