中国肿瘤外科杂志Issue(4)：215-217,3.DOI:10.3969/j.issn.1674-4136.2014.04.004
miR-17在结肠癌中的表达及其临床意义
Clinical significance of miR-17 in expression in colorectal cancer
桂亮 1王太洪 1张弘伟 1卢有胜1
作者信息
- 1. 210009 江苏 南京，南京医科大学附属江苏省肿瘤医院 普外科
- 折叠
摘要
Abstract
Objective To investigate the expression of miR-17 in colorectal cancer(CRC)and its relation-ship with clinicopathological features. Methods Quantitative real-time PCR was applied to examine the expres-sion of miR-17 in 50 primary CRC specimens which were diagnosed and operated in our hospital between 2012. 01 and 2013. 06,in comparison with the corresponding normal mucosa specimens. The relationship between the expression of miRNAs and clinicopathological features was analyzed. Results The expression of miR-17 in CRC was down-regulated by compared to normal mucosa(P ﹤ 0. 05). Furthermore,the expression of miR-17 was related to TNM stage and local invasion(P ﹤ 0. 05). Conclusions The down-expression of miR-17 may play an important role in the progression of CRC.关键词
结肠癌/实时荧光定量/miR-17Key words
colorectal cancer/real-time PCR/miR-17引用本文复制引用
桂亮,王太洪,张弘伟,卢有胜..miR-17在结肠癌中的表达及其临床意义[J].中国肿瘤外科杂志,2014,(4):215-217,3.
