中国肿瘤外科杂志Issue(5)：298-302,5.DOI:10.3969/j.issn.1674-4136.2014.05.009
表皮生长因子受体3在结肠癌中的表达及其与结肠癌细胞增殖凋亡的关系研究
Expression of Her3 in colon cancer and its relationship of proliferation and apoptosis of colon cancer cells
高俊 1吕龙 1陈功1
作者信息
- 1. 211300 江苏 南京，高淳人民医院 普外科
- 折叠
摘要
Abstract
Objective To investigate the expression of Her3 in colon cancer and study the effect and mech-anism of Her3 in colon cancer cell lines. Methods The expression of Her3 in human colon cancer was deter-mined by both real-time PCR and IHC. The possible mechanism was further analyzed by siRNA knock-down as-say in vitro. Results It had werified that expression of Her3 in human colon cancer tissues compared with ad-jacent normal tissues grew sighificantly. Study revealed that knockdown of expression of Her3 led to impaired proliferation and increased apoptosis in human colon cancer cell lines,meanwhile reduced activation of both AKT and MAPK signaling were detected. Conclusions Her3 is excessive expressed in human colon cancer and related to proliferation and survival of colon cancer cell lines in vitro,which is partially due to activation of AKT signaling.关键词
Her3/结肠癌/增殖/凋亡Key words
Her3/colon cancer/proliferation/apoptosis引用本文复制引用
高俊,吕龙,陈功..表皮生长因子受体3在结肠癌中的表达及其与结肠癌细胞增殖凋亡的关系研究[J].中国肿瘤外科杂志,2014,(5):298-302,5.
