中国肿瘤外科杂志Issue(6)：382-384,3.DOI:10.3969/j.issn.1674-4136.2014.06.012
MCP-1基因多态性与食管癌易感性的关系
Relationship between monocyte chemoattactant protein-1 gene polymorphism and susceptibility of esoph-ageal cancer
崔斌 1部春迎 1付萍1
作者信息
- 1. 250200 山东 章丘，章丘市人民医院 肿瘤化疗科
- 折叠
摘要
Abstract
Objective To investigate the association between monocyte chemoattactant protein-1 gene poly-morphism and the susceptibility of ESCC in Han nationality.Methods Polymerase chain reaction (PCR)and DNA direct sequencing were used to detect the MCP-1-2518 gene polymorphism in 202 patients suffering from ESCC,265 healthy patients were chosen as control group.Results The overall genotype and allele distribution of MCP-1-2518 gene polymorphism in the ESCC patients were not significantly different from those in the healthy control group,(P >0.05).There was evidence of stratified analysis based on the smoking case showed that the smokers with AA genotype significantly increased the risk to develop ESCC (sex and age adjusted OR =3.064, 95%CI =1.397 ~6.718)compared with MCP-1-2518 GG genotype.However,MCP-1-2518 allele was no sig-nificantly different from both the non-smoking ESCC group and healthy group,(P >0.05 ).Conclusions MCP-1-2518 gene polymorphism is not independently associated with the susceptibility of ESCC.MCP-1-2518 AA allele may increase the susceptibility of ESCC among smokers in Jinan area.关键词
MCP-1/食管癌/易感性/基因多态性Key words
monocyte chemoattactant protein-1/esophageal cancer/susceptibility/gene polymor-phism引用本文复制引用
崔斌,部春迎,付萍..MCP-1基因多态性与食管癌易感性的关系[J].中国肿瘤外科杂志,2014,(6):382-384,3.
