摘要
Abstract
Objective:The aim of the study was to assess the association between pericardial adipose tissue(PAT) volume with extentof lumens stenosis as detected by coronary computed tomography angiography(CCTA). Methods: This study consisted of 1597 consecutive patients who underwent 320-raw CCTA examination for the evaluation of doubtful coronary artery disease.(males 1090 cases, females 507 cases;age 18-55 years), Of which 382 cases are found arterial plaques.We compared PAT volume in patients with 1-vessel, 2-vessels, 3-vessels and 4-vessels lesion and non-stenosis, respectively. We compared simultaneously PAT volume in patients with coronary atherosclerotic plaques (presence plaque, calcified plaque[CP], non-calcified plaque [NCP], and mixed plaque[MP]) and without coronary atherosclerotic plaques. Results: Pearson correlation and regression analysis showed that PAT volume was positively correlated with numbers of vessel lesionand.Univariate analysis showed the PAT volume in patients with presence of CP, NCP, MP and multi vessel disease larger than those without plaques respectively (211.4±93.6) cm3, (233.2±95) cm3, (257.3±82.1) cm3 and (261.5±101.7) cm3 vs (173.7±98.1) cm3, t=4.89, t=7.11, t=9.66, t=11.65; P<0.05). In multivariate Cox proportional hazards regression analysis, only the PAT volume in patients with MP, multivessel disease and obstructive stenosis was significantly higher than those without plaques (OR=4.79, 2.03-13.16, 95%CI, P<0.001). Conclusion:The PAT volume in patients with presence of coronary plaques, CP, NCP, MP, multivessel disease and obstructive stenosis greater than those without plaque, PAT volume is an important risk factor for coronary heart disease.关键词
心包脂肪组织/体层摄影术,X线计算机/冠心病/斑块Key words
Pericardial adipose tissue/Omography, X-ray computed/Coronary artery disease/Plaque分类
医药卫生
