中国医学装备Issue(1)：87-91,5.
胰腺癌三维适形放射治疗与γ射线体部立体定向放射治疗加量疗效分析
Effect of three-dimensional conformal radiotherapy versus dose boosted with gamma ray ;stereotactic body radiotherapy on locally advanced pancreatic cancer
胡斌 1侯艳丽 1马秀梅 1曹鸿斌 1叶明 1白永瑞1
作者信息
- 1. 上海交通大学医学院附属仁济医院放射诊疗科 上海 200127
- 折叠
摘要
Abstract
Objective:To analyze retrospectively the different efficacy between linear accelerator X-ray with three-dimensional conformal radiotherapy(3D-CRT) and dose boosted with gamma ray stereotactic body radiotherapy(SBRT) for locally advanced pancreatic cancer patients. Methods:A total of 61 patients with locally advanced pancreatic cancer were enrolled. All the patients were first performed by 3D-CRT, the volumes of irradiation included the pancreatic tumor (GTV) and the draining lymph node region, total scheduled dose was 40Gy in 20 fractions. Then boosted the dose to GTV, 21 cases with 3D-CRT(3D-CRT group), total dose of 46Gy;40 cases with SBRT(SBRT group), total dose of 56Gy. Results:The median survival time was 11.3 months for all cases. Patients with pretreatment KPS≥90, combined with chemotherapy and femal had better prognosis. The corresponding MSTs were 14.1 months vs 9.2 months(x2=8.992, P=0.003),13.0 months vs 9.6 months(x2=4.056, P=0.044) and 12.5 months vs 10.7 months(x2=3.953, P=0.047) respectively. The median survival time of 3D-CRT group and SBRT group were 7.5 months and 13 months, P<0.05. There were no statistic differences between 2 groups in terms of side effects induced by treatments. Conclusion:The gamma ray stereotactic body radiotherapy is effective and safe and has the trend to improve the survival rate for patients with locally advanced pancreatic cancer. Patients with better performance status before treatment, combined with chemotherapy and female may have better prognosis.关键词
胰腺癌/三维适形放疗/γ射线体部立体定向放疗Key words
Pancreatic cancer/3D-conformal radiotherapy/Gamma ray stereotactic body radiotherapy分类
医药卫生引用本文复制引用
胡斌,侯艳丽,马秀梅,曹鸿斌,叶明,白永瑞..胰腺癌三维适形放射治疗与γ射线体部立体定向放射治疗加量疗效分析[J].中国医学装备,2015,(1):87-91,5.
