中国医学装备Issue(5)：16-19,4.DOI:10.3969/J.ISSN.1672-8270.2015.05.005
伽玛刀治疗肺癌脑转移瘤的远期生存分析
Long-term survival analysis for patients with brain metastases of pulmonary cancer undergoing Gamma Knife surgery
摘要
Abstract
Objective: To analyze the clinical characteristics of patients with brain metastases of pulmonary cancer undergoing Gamma Knife radiosurgery and discuss the influencing factors of long-term survival. Methods: The clinical characteristics of 132 cases with brain metastases of pulmonary cancer undergoing Gamma Knife surgery were collected retrospectively. Age, gender, pathological type, position, size, quantity, extracranial metastases, KPS and PRA score before radiosurgery, and interval of diagnosis between primary lesion and brain metastases were recorded. Log-rank method and Cox regression model were employed to perform univariate and multivariate analysis respectively for long-term survival. Results: Median survival time was 22 months and accumulative survival rate was 66.67%at 12 months, 26.52%at 24 months, 9.85%at 36 months, 1.52%at 48 months, respectively. Pathological type, position, quantity, extracranial metastases, KPS and PRA score before radiosurgery, et al were revealed as the factors significantly related to long-term survival by log-rank analysis. Then, extracranial metastases and PRA score before radiosurgery were shown as independent predictors for long-term survival by Cox regression model. Conclusion:Primary tumor controlling actively combined with effective Gamma Knife radiosurgery plays a predominant role to improve the long-term prognosis for patients with brain metastases of pulmonary cancer.关键词
脑转移瘤/肺癌/伽玛刀/随访/预后Key words
Brain metastases/Pulmonary cancer, Gamma knife surgery/Follow-up/Prognosis分类
医药卫生引用本文复制引用
俞建臣,汤可,赵亚群,赵莉,高冬晓,高浩..伽玛刀治疗肺癌脑转移瘤的远期生存分析[J].中国医学装备,2015,(5):16-19,4.基金项目
首都卫生发展科研专项(2014-4-5073)“计算机桥小脑角区手术虚拟现实微创化检验和临床实践” （2014-4-5073）
