中国医学装备Issue(6)：66-69,70,5.DOI:10.3969/J.ISSN.1672-8270.2015.06.020
18F-FDG PET/CT评价鼻咽癌治疗后的肿瘤残留或复发
18F-FDG PET-CT for detection of residual/recurrent nasopharyngeal carcinoma after therapy
摘要
Abstract
Objective:To investigate the diagnostic potential of 18F-FDG PET-CT for the detection of residual/recurrent nasopharyngeal carcinoma(NPC). Methods:Fifty-five NPC patients after therapy underwent follow-up with PET-CT. In 55 NPC, thirty-eight NPC patients were performed with both PET-CT and NPS, and thirty-one NPC patients with both PET-CT and MRI. The diagnosis standards were based on histopathological findings or clinical and imaging follow-up above 6 months. The sensitivity, specificity, and accuracy of PET-CT were analyzed, and an optimal cut-off of SUVmax was determined. PET-CT, NPS and MRI were compared for local residual or recurrent nasopharygeal carcinoma with receiver operating characteristic curves (ROC). The detection of neck lymph node metastasis, distant metastasis and second primary carcinoma were analyzed with PET-CT. Results:The sensitivity, specificity and accuracy of PET-CT were 100%, 87.9%, 92.7%for local residual/recurrent nasopharygeal carcinoma. The optimal cut-off of SUVmax was 4.2 for local tumor residual/recurrence. PET-CT showed better diagnostic accuracy than NPS(P<0.05), and similar accuracy to MRI (P>0.05). The detection of neck lymph node metastasis, distant metastasis and second primary carcinoma in NPC was 14.5%, 10.9%and 5.5%with PET-CT. Conclusion:PET-CT had a high accuracy of local residual/recurrent NPC at the primary tumor site and detection of neck lymph node metastasis, distant metastasis and second primary carcinomas. PET-CT would more comprehensive for tumor restaging and therapy strategy.关键词
肿瘤残留或复发/鼻咽肿瘤/体层摄影术,正电子发射/氟脱氧葡萄糖/磁共振成像/纤维鼻咽镜检查Key words
Neo plasmas residue or recurrence/Nasopharyngeal/Tomography, positron emission/Fluorodeoxyglucose/Magnetic resonance imaging/Naso phargo fiberscope分类
医药卫生引用本文复制引用
梁颖,吴宁,耿建华,罗德红,方艳,郑容,张雯杰,刘瑛,李小萌..18F-FDG PET/CT评价鼻咽癌治疗后的肿瘤残留或复发[J].中国医学装备,2015,(6):66-69,70,5.基金项目
中国癌症基金会北京希望马拉松专项基金(LC2008B42)“PET/CT评价淋巴瘤治疗后残存肿块” （LC2008B42）
