中国药业Issue(12)：46-47,48,3.
阿托伐他汀联合依折麦布治疗急性冠脉综合征47例临床研究
Clinical Study of Atorvastatin Combined with Ezetimibe in Treating Acute Coronary Syndrome in 47 Cases
王华 1陈婧 1赵晓辉2
作者信息
- 1. 重庆市沙坪坝区人民医院，重庆 400030
- 2. 中国人民解放军第三军医大学第二附属医院，重庆 400037
- 折叠
摘要
Abstract
Objective To observe the clinical efficacy and safety of atorvastatin combined with ezetimibe for treating acute coronary syn-drome. Methods 94 cases of acute coronary syndrome were randomly divided into the observation group and the control group with 47 cases in each group. The patients in the control group were given atorvastatin 20 mg / d,while the patients in the observation group re-ceived atorvastatin 20mg plus ezetimibe 10 mg / d by oral administration before sleeping. All patients were treated for 4 weeks. The plas-ma lipids and hypersensitive C - reactive protein(hs - CRP)before and after treatment were detected. The short term reaching standard rate of blood lipids and the clinical safety were compared between the groups. Results After therapy,the TC,TG,LDL - C and hs -CRP levels in the two groups were significantly reduced( P < 0. 05),but the improvement of the indexes in the observation group were significantly superior to that in the control group( P < 0. 05);compared with before treatment,the HDL - C level after treatment in the observation group was significantly increased( P < 0. 05) and was more significant compared with the control group( P < 0. 05). The HDL - C level after treatment in the control group was increased without statistically significant difference( P > 0. 05);the reaching standard rate of blood lipids in the observation group was 53. 19% ,which was significantly higher than 27. 66% in the control group ( P < 0. 05);the recurrent rates of angina and acute myocardial infarction in the observation group were significantly lower than those in the control group( P < 0. 05)and other adverse reactions had no statistically significant difference between the two groups( P > 0. 05). Conclusion Atorvastatin combined with ezetimibe has the definite effect in treating acute coronary syndrome,can significantly increase the reaching standard rate of blood lipids and reduce the occurrence rate of cardiovascular events with good safety.关键词
阿托伐他汀/依折麦布/急性冠脉综合征/疗效/安全性Key words
atorvastatin/ezetimibe/acute coronary syndrome/effectiveness/safety分类
医药卫生引用本文复制引用
王华,陈婧,赵晓辉..阿托伐他汀联合依折麦布治疗急性冠脉综合征47例临床研究[J].中国药业,2014,(12):46-47,48,3.
