摘要
Abstract
Objective To introduce the action mechanisms of Cyclosporin A ( CsA ) Eye Drops for treating dry eye syndrome and the re-lated clinical research progress. Methods The electronic retrieval from the National Center for Biotechnology Information databases was performed by using the key words cyclosporine, cyclosporin A, mechanism and external preparation and the research literatures in the near 10 years were consulted. The research history, mechanisms for treating dry eye syndrome and the related clinical research progress were summarized. Results CsA Eye Drops appeared in market as the drug RestasisTM. Its action mechanisms for treating dry eye syn-drome include the immunosuppression, antiapoptosis, increasing goblet cell density and the mucin secretion level, and increasing tears flow, etc. Its long term clinical application is safe and effective without systemic adverse reactions, and can significantly improve the dis-comfort symptoms of dry eye syndrome. Conclusion The external preparation of CsA Eye Drops for treating dry eye syndrome has many action mechanisms, its clinical application has good effect and less adverse reactions, which can be used for a long time.关键词
环孢素A/滴眼液/干眼症/作用机制Key words
cyclosporin A/eye drop/dry eye syndrome/action mechanism分类
医药卫生
