摘要
Abstract
Objective To develop a high performance liquid chromatography ( HPLC ) method for the content determination of chlorpheni-ramine maleate in Xiaoer Anfen Huang Namin Granules. Methods The Lichrospher C18 column ( 200 mm × 4. 6 mm, 5μm ) was adopted;the mobile phase was acetonitrile-0. 5% sodiuam lauryl sulfate-phosphoric acid ( 60 : 40 : 0. 1 ); the flow rate was 1. 0 mL/min;the injection volume was 20 μL; the detection wavelengh was 210 nm. Results The linear range of chlorpheniramine maleate was 6. 37-42. 50 μg/mL ( r=0. 999 5, n=5 ) , the average recovery rate was 100. 18%, RSD=1. 19% ( n=9). Conclusion This method is simple, rapid, accurate and repeatable.关键词
小儿氨酚黄那敏颗粒/马来酸氯苯那敏/高效液相色谱法Key words
Xiaoer Anfen Huang Namin Granules/chlorphenamine maleate/high performance liquid chromatography
