摘要
Abstract
Objective To observe the effect and complications of methotrexate combined with prednisone in treating rheumatoid arthritis ( RA ) and to discuss the nursing strategy. Methods 100 cases of RA treated in our hospital from January 2012 to October 2013 were selected and randomly divided into the observation group and the control group, 50 cases in each group. The control group used the methotrexate therapy, while the observation group adopted the therapy of methotrexate combined with prednisone. The curative effects after treatment, average ESR, CRP, RF, average morning stiffness, griping power and adverse reactions were observed in the two groups. Results The significantly effective rate of the observation group was 44. 00%, which was higher than 34. 00% in the contorl group ( P﹤0. 05 );the ineffective rate of the observation group was 4. 00%, which was lower than 12. 00% of the control group ( P﹤0. 05 );the morning stiff-ness after treatment in the observation group was ( 2. 21 ± 0. 08 ) h, which was lower than ( 2. 57 ± 0. 10 ) h in the control group ( P﹤0. 05 );the gripping power of the observation group was ( 12. 85 ± 0. 41 ) kPa, which was higher than ( 10. 69 ± 0. 58 ) kPa of the control group ( P﹤0. 05 );the average ESR, CRP and RF of the observation group were ( 24. 36 ± 0. 93 ) mm/h, ( 11. 22 ± 0. 48 ) mg/L and 11. 53 ± 0. 40 respectively, which were lower than ( 28. 71 ± 1. 48 ) mm/h, ( 13. 15 ± 0. 50 ) mg/L and 14. 07 ± 0. 68 of the control group ( P﹤ 0. 05 ) . The major adverse reactions between the two groups had no statistically significant difference. Conclusion Methotrexate combined with pred-nisone for treating RA has significantly clinical effect and obviously improve the patient's symptoms and the main indicators. The ratio-nal nursing under this basis also conduces to alleviate the patient's condition.关键词
甲氨蝶呤/强的松/类风湿关节炎/护理Key words
methotrexate/prednisone/rheumatoid arthritis/nursing分类
医药卫生
