中国药业Issue(14)：33-34,35,3.
帕罗西汀联合喹硫平治疗抑郁症的疗效观察
Efficacy of Paroxetine Combined with Quetiapine in Treating Depressive Disorder
袁刚 1杨通林2
作者信息
- 1. 重庆市精神卫生中心女病区，重庆 401147
- 2. 重庆市长寿区精神病医院，重庆 401221
- 折叠
摘要
Abstract
Objective To observe the efficacy and safety of paroxetine combined with quetiapine in treating depressive disorder. Methods 55 inpatients with depressive disorder in the psychiatric specialist hospital were randomly divided into 2 groups. The course of treatment was 4 weeks. The effects were evaluated by the Hamilton Rating Scale for Depression(HRSD)and the adverse reactions were evaluat-ed by the Treatment Emergent Symptom Scale(TESS). The repeated measures analysis of variance(ANOVA)was adopted to compare the initial effect time and effects between paroxetine combined with quetiapine and single paroxetine in treating depressive disor-der. Results Throughout the 4 - week treatment course,the interactions existed between group and time( F = 7. 107 P = 0. 000),while no statistically difference existed among adverse reactions( χ2 = 0. 162 P = 0. 688 ﹥ 0. 05). The efficacy at the end of 4 weeks had sta-tistical difference between the two groups( t = 5. 720 P = 0. 000 ﹤ 0. 05). Conclusion The initial effect time and effect of paroxetine combined with quetiapine in treating depressive disorder are superior to single use of paroxetine. The combination medication does not increase the adverse drug reactions.关键词
抑郁症/帕罗西汀/喹硫平Key words
depressive disorder/paroxetine/quetiapine分类
医药卫生引用本文复制引用
袁刚,杨通林..帕罗西汀联合喹硫平治疗抑郁症的疗效观察[J].中国药业,2014,(14):33-34,35,3.
