中国药业Issue(16)：22-24,3.
均匀设计法优选酸枣仁抗抑郁有效组分配伍研究
Compatibility of Effective Antidepressant Components of semen Ziziphi spinosae Based on Uniform Design Method
摘要
Abstract
Objective To optimize the best compatibility of effective antidepressant components (total fat oil, total flavonoids, total saponins) of Semen Ziziphi Spinosae. Methods 90 mice were randomly divided into 9 groups, the control group and administration A -H groups by the uniform design method. The mice forced swimming and the tail suspension test in each group were observed. With the immobility time at latter 4 min within 6 min as the evaluating index, the best compatibility of effective antidepressant components was screened. The pharmaceutical effects of obtained optimal compatibility of the effective components were to be proved by the comparison and verification experiment. Results The immobility time of mice during the forced swimming test in the administration A, B, C, F, H groups were significantly less than those in the control group( P < 0. 05); the immobility time of mice during the tail suspension test in the administration A, B, D, E, F, H groups were significantly less than those in the control group( P < 0. 05, P < 0. 01). After the multivariate statistical analysis, the optimal compatibility of effective antidepressant components of Semen Ziziphi Spinosae was total fat oil 10 mg / kg, to-tal flavonoids 100 mg / kg and total saponins 10 mg / kg. Conclusion The compatibility of effective components determined by the combina-tion of the uniform design, mathematical statistics and pharmacodynamics is feasible, the pharmaceutical effect of optimized active component compatibility reaches or surpasses that of the original medicinal materials.关键词
酸枣仁/组分配伍/均匀设计/抗抑郁Key words
Semen Ziziphi Spinosae/effective components/uniform design/antidepressant引用本文复制引用
赵启铎,舒乐新,高岚..均匀设计法优选酸枣仁抗抑郁有效组分配伍研究[J].中国药业,2014,(16):22-24,3.基金项目
天津市高等学校发展项目基金，项目编号20070305。 （）
