中国药业Issue(16)：53-53,54,2.
石墨炉原子吸收光谱法测定福沙吡坦中痕量钯
Determination of Trace Palladium in Fosaprepitant by Graphite Furnace Atomic Absorption Spectrometry
颜琳琦 1李樱红 1郭旺明2
作者信息
- 1. 浙江省食品药品检验研究院，浙江 杭州 310004
- 2. 杭州九源基因工程有限公司，浙江 杭州 310018
- 折叠
摘要
Abstract
Objective To establish a method for the determination of trace palladium(Pd)in fosaprepitant and to verify the effect of the Pd-removing process. Methods The microwave digesting method was adopted to process the sample,the Pd residual amount in fos-aprepitant was detected by the graphite furnace atomic absorption spectrometry(AAS) method. Results The mass concentration of Pd within the concentration range of 5-50 μg/L showed the good linear relation with the absorbance( r=0. 999 9). The limit of detection (LOD) was 1. 68 μg/L,the minimal detectable concentration in the sample was 0. 22 μg/g and the average recovery rate was 100. 82% ,RSD=3. 34%( n=9). Conclusion Adopting this method is sensitive,accurate and reliable for detecting the Pd residual amount in fosaprepitant and provides the basis for the quality control of this drug.关键词
石墨炉原子吸收分光光度法/钯/福沙吡坦Key words
graphite furnace atomic absorption spectrometry/palladium/fosaprepitant分类
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颜琳琦,李樱红,郭旺明..石墨炉原子吸收光谱法测定福沙吡坦中痕量钯[J].中国药业,2014,(16):53-53,54,2.
