中国药业Issue(17)：30-31,32,3.
心脉隆注射液对老年慢性心力衰竭患者脑钠肽前体及肌钙蛋白Ⅰ的影响
Effects of Xinmailong Injection on Pro-Brain Natriuretic Peptide and TroponinⅠin Elderly Patients with Chronic Heart Failure
摘要
Abstract
Objective To investigate the effects of Xinmailong Injection on pro-brain natriuretic peptide ( proBNP ) and troponin Ⅰ( CTnⅠ) in elderly patients with chronic heart failure ( CHF ) Methods 92 inpatients aged over 70 years with CHF were collected and randomly divided into the two groups. The control group ( 43 cases ) was given the CHF conventional treatment, while on this basis the Xinmailong group ( 49 cases ) was added with Xinmailong Injection 300 mg/d by intravenous drip for 14 d. The levels of proBNP and CtnI were detected and the 6-min walk test ( 6MWT ) was performed before and after treatment. Results Among 92 cases, with the NYHA cardiac functional grading increase, the levels of CTnI and proBNP were elevated, while the distance of 6MWT was decreased;af-ter 14 d treatment, the CTnI and proBNP levels of the two groups were decreased, while the distance of 6MWT was raised compared with before treatment; the proBNP and CTnI levels after treatment in the Xinmailong group lower than those in the control group [ ( 410. 97 ± 74. 56 ) pg/mL vs. ( 476. 75 ± 80. 21 ) pg/mL, P=0. 000; ( 0. 06 ± 0. 03 ) ng/mL vs. ( 0. 08 ± 0. 04 ) ng/mL, P=0. 008 ];the dis-tance of 6MWT in the Xinmailong group was increased compared with the control group [ ( 431. 78 ± 42. 58 ) m vs. ( 406. 25 ± 46. 31 ) m, P=0. 007 ) . Conclusion Xinmailong Injection can improve the heart function in elderly patients with CHF.关键词
心脉隆注射液/慢性心力衰竭/肌钙蛋白Ⅰ/脑钠肽前体Key words
Xinmailong Injection/chronic heart failure/troponin I/pro-brain natriuretic peptide分类
医药卫生引用本文复制引用
杨海燕,曹明晶,傅朝晖..心脉隆注射液对老年慢性心力衰竭患者脑钠肽前体及肌钙蛋白Ⅰ的影响[J].中国药业,2014,(17):30-31,32,3.基金项目
重庆市卫生局科研基金资助项目，项目编号2013-2-090。 （）
